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Prolactin Secretion Following Repetitive Seizures Neurol 45:448-452, Malkowicz,D.E.,et al, 1995 See this aricle in Pubmed Article Abstract We studied serum prolactin levels after 24 seizures occurring in eight subjects.Video-EEG intracranial monitoring confirmed temporal or frontal partial seizures.Seizure type,focus,and duration were similar for seizures with and without significant postictal prolactin elevations.The seizure- free interval(the time between seizures)varied considerably.Seizures occurring after longer seizure-free intervals(31.75 to 240 hours)showed robust prolactin responses.After shorter seizure-free intervals(1.07 to 25.42 hours),prolactin responses were reduced.This suggests that the amount of releasable prolactin is limited,depleted by seizures,or perhaps inhibited by prolactin feedback.Seizure-free intervals should be considered when interpreting prolactin levels.

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